Anti-androgenic activity of Myricae Cortex--isolation of active constituents from bark of Myrica rubra.

نویسندگان

  • H Matsuda
  • M Yamazaki
  • K Matsuo
  • Y Asanuma
  • M Kubo
چکیده

The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra Sieb. et Zucc., Myricaceae) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.

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عنوان ژورنال:
  • Biological & pharmaceutical bulletin

دوره 24 3  شماره 

صفحات  -

تاریخ انتشار 2001